In stochastic population genetics, the fundamental quantity used for describing the genetic composition of a Mendelian population is the gene frequency. The process of change in the gene frequency is generally modeled as a stochastic process satisfying a stochastic differential equation. The drift and diffusion coefficients in this equation reflect such mechanisms as mutation, selection, and migration that affect the population. Except in very simple cases, it is difficult to determine the probability law of the stochastic process of change in gene frequency. We present a method for obtaining approximations of this process, enabling us to study models more realistic than those treated previously, called the Gauss Galerkin method.
Abrouk, Nacer E. and Lopez, Robert J., "Population Genetics: Estimation of Distributions through Systems of Non-Linear Differential Equations" (1995). Mathematical Sciences Technical Reports (MSTR). 65.